Reaktion #1606739

Reaktionsgleichung

1-[2-(4-nitrophenyl)ethyl]piperazine

1-bromo-4-(2-bromoethyl)benzene

triethylamine

→

desired product

1-[2-(4-bromophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine

Lösungsmittel

DMF

Reaktionsbedingungen

Vorschrift

A solution of 1-[2-(4-nitrophenyl)ethyl]piperazine (300 mg, 1.3 mmol), 1-bromo-4-(2-bromoethyl)benzene (400 mg, 1.5 mmol), and triethylamine (0.89 mL, 6.4 mmol) in DMF (5 mL) was heated to 60° C. for 16 hours. LC showed formation of the desired product. The desired product was purified by silica gel chromatography (10% MeOH in EtOAc). LC-MS (IE, m/z): 420 (M+1)+.

Quelle