Reaktion #1606467

Reaktionsgleichung

2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester

Intermediate 4

2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester

2-fluoro-4-methoxyphenacyl bromide

→

4-[4-(2-Fluoro-4-methoxy-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid

Ausbeute 89.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedescribed for the preparation of Example 1

Vorschrift

4-[4-(2-Fluoro-4-methoxy-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (253 mg, 89%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-fluoro-4-methoxyphenacyl bromide (available from ASDI Incorporated) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 8.54 (d, J=1.8 Hz, 1H), 8.10-8.21 (m, 3H), 7.94 (d, J=2.4 Hz, 1H), 7.59-7.78 (m, 2H), 7.39 (d, J=8.0 Hz, 2H), 6.93-7.02 (m, 2H), 3.83 (s, 3H).

Quelle