Reaktion #1605821

Reaktionsgleichung

5-Acetyl-8-hydroxy-1H-quinolin-2-one

potassium carbonate

4-methoxybenzyl chloride

→

5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one

Ausbeute 53.8%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo the reaction mixture was added
2. 2
   Sonstigepurified water (0.5 L)
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature overnight
4. 4
   FiltrationThe precipitate was collected by filtration
5. 5
   Waschenwashed with purified water
6. 6
   Sonstigedried under reduced pressure

Vorschrift

5-Acetyl-8-hydroxy-1H-quinolin-2-one (29.5 g, 0.15 mol) was suspended in N,N-dimethylformamide (145 mL), potassium carbonate (22.2 g, 0.16 mol) and successively 4-methoxybenzyl chloride (22.7 g, 0.15 mol) were added thereto, and the mixture was stirred at 90° C. overnight. To the reaction mixture was added purified water (0.5 L) and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, dried under reduced pressure to obtain 5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one (26.1 g).

Quelle