Reaktion #1605816

Reaktionsgleichung

boron tribromide

4-Methoxy-2-nitro-1-phenylbenzene

→

3-nitro-4-phenylphenol

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added, under ice-water cooling
2. 2
   workup.ADDITIONthe reaction mixture was poured onto ice
3. 3
   Sonstigethe reaction
4. 4
   Extraktionextracted with ethyl acetate
5. 5
   WaschenThe organic layer was washed with a saturated aqueous solution of sodium chloride
6. 6
   Trocknendried over anhydrous magnesium sulfate
7. 7
   Einengenconcentrated under reduced pressure

Vorschrift

4-Methoxy-2-nitro-1-phenylbenzene (1.86 g, 8.31 mmol) was dissolved in dichloromethane (40 mL) and thereto was added, under ice-water cooling, a solution of boron tribromide (2 mL) in dichloromethane (10 mL) After stirring at room temperature for 18 hours, the reaction mixture was poured onto ice to stop the reaction and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylphenol as a crude material.

Quelle