Reaktion #1605805

Reaktionsgleichung

4-(3-Amino-4-phenylphenyl)butyric acid

tosylic acid hydrate

water

→

benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate

Ausbeute 171.2%

Lösungsmittel

toluene

benzyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added
2. 2
   Temperaturthe mixture was heated
3. 3
   Sonstigeremoved by a Dean-Stark trap
4. 4
   EinengenThe reaction solution was concentrated under reduced pressure
5. 5
   Sonstigea solid obtained
6. 6
   Waschenwas washed with a mixed solvent of hexane-ethyl acetate (4:1)
7. 7
   FiltrationThe solid was collected by filtration
8. 8
   Sonstigedried under reduced pressure

Vorschrift

To a suspension of 4-(3-Amino-4-phenylphenyl)butyric acid (21.6 g, 84.6 mmol) in toluene (300 mL), benzyl alcohol (50 mL) and tosylic acid hydrate (17.7 g, 93.0 mmol) were added, and the mixture was heated under reflux for 5 hours with water removed by a Dean-Stark trap. The reaction solution was concentrated under reduced pressure and a solid obtained was washed with a mixed solvent of hexane-ethyl acetate (4:1). The solid was collected by filtration and dried under reduced pressure to obtain benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate (41.2 g).

Quelle