Reaktion #1605751

Reaktionsgleichung

2-methylheptan-4-one

ammonium acetate

sodium cyanoborohydride

→

2-methylheptan-4-amine

Ausbeute 77.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was diluted with water and basified with 15% NaOH aqueous
3. 3
   Extraktionextracted with ether
4. 4
   WaschenThe extract was washed with brine
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Sonstigeevaporated

Vorschrift

To a solution of 2-methylheptan-4-one (4.24 g, 33.07 mmol), in methanol (60 mL), were added ammonium acetate (25.50 g, 330.71 mmol) and sodium cyanoborohydride (2.08 g, 33.07 mmol). The reaction mixture was stirred at room temperature for about 24 hours. The solvent was removed under reduced pressure and the residue was diluted with water and basified with 15% NaOH aqueous and extracted with ether. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated to give 3.3 g of 2-methylheptan-4-amine (77%). MS (M+H, 130).

Quelle