Reaktion #1605383

Reaktionsgleichung

[2-(4-amino-phenyl)-ethyl]-carbamicacid tert-butyl ester

4-Isopropyl-benzenesulfonyl chloride

→

product

Ausbeute 109.3%

{2-[4-(4-Isopropyl-benzenesulfonylamino)-phenyl]-ethyl}-carbamic acid tert-butyl ester

Ausbeute 109.3%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat 0° C
2. 2
   EinengenAfter concentration in vacuo the residue
3. 3
   Sonstigewas partitioned between dichloromethane and saturated aqueous NaHCO3
4. 4
   WaschenThe organic layer was washed with water
5. 5
   Trocknendried over MgSO4
6. 6
   Filtrationfiltered
7. 7
   Sonstigethe solvent evaporated under reduced pressure

Vorschrift

To a solution of [2-(4-amino-phenyl)-ethyl]-carbamicacid tert-butyl ester (10.75 g, 45.49 mmol) in pyridine (125 ml) at 0° C. 4-Isopropyl-benzenesulfonyl chloride (10.45 g, 47.76 mmol) was added. The mixture was stirred at 0° C. for 1 h and 16 h at room temperature. After concentration in vacuo the residue was partitioned between dichloromethane and saturated aqueous NaHCO3. The organic layer was washed with water, dried over MgSO4, filtered and the solvent evaporated under reduced pressure to give the product as a brown oil (20.82 g, 50%).

Quelle