Reaktion #160526

Reaktionsgleichung

hydrochloric acid

1,4-difluoro-2-methyl-5-nitrobenzene

cyanoacetic acid benzyl ester

potassium carbonate

→

title compound

Ausbeute 81.4%

Cyano-(4-fluoro-5-methyl-2-nitrophenyl)acetic acid benzyl ester

Ausbeute 81.4%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthis mixture was extracted with diethyl ether
2. 2
   WaschenThis organic layer was washed with brine
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   SonstigeThe solvent was removed under reduced pressure
6. 6
   WaschenThis residue was washed with ethanol

Vorschrift

A suspension of 1,4-difluoro-2-methyl-5-nitrobenzene (1.00 g), cyanoacetic acid benzyl ester (1.01 g) and potassium carbonate (1.76 g) in N,N-dimethylformamide (20.0 mL) was stirred at 60° C. for 1 day. To this reaction mixture was added 1 mol/L hydrochloric acid (25.4 mL), and this mixture was extracted with diethyl ether. This organic layer was washed with brine, and dried over anhydrous magnesium sulfate, and filtered. The solvent was removed under reduced pressure. This residue was washed with ethanol to give the title compound (1.54 g).

Quelle