Reaktion #160504

Reaktionsgleichung

water

6-fluoro-1H-indole-3-carbaldehyde

hydroxylamine

sodium formate

→

title compound

Ausbeute 59.9%

6-Fluoro-1H-indole-3-carbonitrile

Ausbeute 59.9%

Lösungsmittel

formic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to ambient temperature
2. 2
   Filtrationthe precipitated solid was collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried

Vorschrift

To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).

Quelle