Reaktion #160295

ord-91a51b63eee745879a22584cc0b04ac1

Reaktionsgleichung

FC(F)(F)c1cnc(Cl)c(Cl)c1
2,3-dichloro-5-(trifluoromethyl)pyridine
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(cnn3C3CC3)c2)c(Cl)c1
ethyl 3-chloro-4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(cnn3C3CC3)c2)c(Cl)c1
Ethyl 3-chloro-4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate
→
CCOC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(cnn3C3CC3)c2)c2ncc(C(F)(F)F)cc2Cl)c(Cl)c1
titled compound
CCOC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(cnn3C3CC3)c2)c2ncc(C(F)(F)F)cc2Cl)c(Cl)c1
Ethyl 3-chloro-4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

Edukte

FC(F)(F)c1cnc(Cl)c(Cl)c1
2,3-dichloro-5-(trifluoromethyl)pyridine
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(cnn3C3CC3)c2)c(Cl)c1
ethyl 3-chloro-4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate
CCOC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(cnn3C3CC3)c2)c(Cl)c1
Ethyl 3-chloro-4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and ethyl 3-chloro-4-(N-((1-cyclopropyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-1 of Example 31).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08829026B2uspto-grants-2014_09