Reaktion #160256

ord-4c44a4105bd74c26856757d29870f12b

Reaktionsgleichung

FC(F)(F)c1cnc(Cl)c(Cl)c1
2,3-dichloro-5-(trifluoromethyl)pyridine
COC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(ccn3C)c2)c(C)c1
methyl 3-methyl-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate
→
COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(ccn3C)c2)c2ncc(C(F)(F)F)cc2Cl)c(C)c1
titled compound
COC(=O)c1ccc(S(=O)(=O)N(Cc2ccc3c(ccn3C)c2)c2ncc(C(F)(F)F)cc2Cl)c(C)c1
Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)-3-methylbenzoate

Edukte

FC(F)(F)c1cnc(Cl)c(Cl)c1
2,3-dichloro-5-(trifluoromethyl)pyridine
COC(=O)c1ccc(S(=O)(=O)NCc2ccc3c(ccn3C)c2)c(C)c1
methyl 3-methyl-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and methyl 3-methyl-4-(N-((1-methyl-1H-indol-5-yl)methyl)sulfamoyl)benzoate (step-2 of Example 11).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08829026B2uspto-grants-2014_09