Reaktion #1600904

Reaktionsgleichung

Butyllithium

2-methylthiazole

Chlorotrimethylstannane

→

2-methyl-5-(trimethylstannyl)thiazole

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGStirring
2. 2
   workup.WAITwas continued at −78° C. for 45 min
3. 3
   SonstigeThe reaction mixture was quenched with a satured aqueous solution of NaHCO3
4. 4
   ExtraktionThe aqueous layer was extracted with Et2O
5. 5
   TrocknenThe organic extracts were dried over MgSO4
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeUsed in the next step without purification (obtained 1.29 g)

Vorschrift

Butyllithium (1.6M in THF, 3.5 ml, 5.5 mmol) was added to a stirred solution of 2-methylthiazole (0.45 ml, 5.0 mmol) in THF (15 mL) at −78° C. The reaction mixture was stirred at −78° C. for 40 min. Chlorotrimethylstannane (1M in THF, 5.0 ml, 5.0 mmol) was added. Stirring was continued at −78° C. for 45 min. The reaction mixture was quenched with a satured aqueous solution of NaHCO3. The aqueous layer was extracted with Et2O. The organic extracts were dried over MgSO4, filtered and concentrated in vacuo. Used in the next step without purification (obtained 1.29 g). MS m/z=264.1. Calc'd for C ,7; H, 13; N, S, Sn: 261.94.

Quelle