Reaktion #160064

Reaktionsgleichung

Hydrogen chloride

tert-butyl 10-(5-methylthiazol-2-yl)-8-(2,2,2-trifluoroethyl)-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate

→

10-(5-methylthiazol-2-yl)-8-(2,2,2-trifluoroethyl)-11-oxa-3,8-diazaspiro[5.5]undecane hydrochloride salt

Ausbeute 110.6%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe excess HCl and solvent were removed under reduced pressure

Vorschrift

Hydrogen chloride (229 μL of 4 M solution in dioxane, 0.9160 mmol) was added to tert-butyl 10-(5-methylthiazol-2-yl)-8-(2,2,2-trifluoroethyl)-11-oxa-3,8-diazaspiro[5.5]undecane-3-carboxylate (95 mg, 0.18 mmol) in anhydrous dichloromethane (1 mL) and the reaction mixture was stirred for 2 hours at room temperature. The excess HCl and solvent were removed under reduced pressure to yield 10-(5-methylthiazol-2-yl)-8-(2,2,2-trifluoroethyl)-11-oxa-3,8-diazaspiro[5.5]undecane hydrochloride salt (74 mg, 99%) as a light yellow solid. ESI-MS m/z calc. 335.1. Found 336.5 (M+1)+; Retention time: 0.91 minutes (3 min run).

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