Reaktion #1599849

ord-aa1829cabb6846dc90a95ea15018a2bb

Reaktionsgleichung

Cc1noc(-c2ccc(Br)cc2)c1C=O
5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde
CC(C)([CH2][Mg][Cl])c1ccccc1
2-methyl-2-phenylpropylmagnesium chloride
→
Cc1noc(-c2ccc(Br)cc2)c1C(O)CC(C)(C)c1ccccc1
1-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-3-methyl-3-phenyl-butan-1-ol

Edukte

Cc1noc(-c2ccc(Br)cc2)c1C=O
5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde
CC(C)([CH2][Mg][Cl])c1ccccc1
2-methyl-2-phenylpropylmagnesium chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared according to the procedure described in Example 35, Step 3, using 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde and 2-methyl-2-phenylpropylmagnesium chloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08217066B2uspto-grants-2012_07