Reaktion #1599846

Reaktionsgleichung

5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine

4-(3-trifluoromethyl-phenyl)-butan-2-one

→

[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-[1-methyl-3-(3-trifluoromethyl-phenyl)-propyl]-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige: Prepared
2. 2
   SonstigeAfter silica gel chromatography the crude material was purified via preparatory chiral HPLC (Chiralcel-AD column, 2% EtOH in hexanes, 35 minutes)
3. 3
   Sonstigeto afford two
4. 4
   Sonstigeseparate enantiomers
5. 5
   WaschenThe first enantiomer eluted from the column

Vorschrift

: Prepared according to the procedure described in Example 8, Step 1, using 5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylamine and 4-(3-trifluoromethyl-phenyl)-butan-2-one. After silica gel chromatography the crude material was purified via preparatory chiral HPLC (Chiralcel-AD column, 2% EtOH in hexanes, 35 minutes) to afford two separate enantiomers. The first enantiomer eluted from the column is the title compound.

Quelle