Reaktion #159955

Reaktionsgleichung

Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate

monoethyl malonate

piperidine

→

title compound

Ausbeute 47.7%

Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxyate

Ausbeute 47.7%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitate was recovered by filtration
2. 2
   WaschenThe precipitate was washed with water
3. 3
   Sonstigedried
4. 4
   Temperaturunder heating

Vorschrift

Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.

Quelle