Reaktion #159939

Reaktionsgleichung

ethyl 4-fluoro-3-nitrobenzoate

2-isopropylimidazole

N,N-diisopropylethylamine

→

title compound

Ausbeute 81.7%

Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate

Ausbeute 81.7%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 24 hours
3. 3
   workup.DISTILLATIONAfter distilling the solvent off, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   WaschenThe organic layer was washed with brine
7. 7
   Trocknendried over magnesium sulfate
8. 8
   Sonstigeremoved of the solvent by distillation

Vorschrift

A mixture of ethyl 4-fluoro-3-nitrobenzoate 4.26 g, 2-isopropylimidazole 2.20 g, N,N-diisopropylethylamine 5.2 mL and acetonitrile 40 mL was heated under reflux for 24 hours. After distilling the solvent off, water was added to the residue and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation, to provide 4.95 g of the title compound.

Quelle