Reaktion #1597437

Reaktionsgleichung

tert-butyl[(1S)-1-benzyl-2-oxo-2-{[4-(4-pyridinyl)phenyl]amino}ethyl]carbamate

hydrogen chloride

→

(2S)-2-amino-3-phenyl-N-[4-(4-pyridinyl)phenyl]propanamide dihydrochloride

Lösungsmittel

ethanol

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents were removed by evaporation in vacuo
2. 2
   Sonstigethe residue was recrystallized from 2-propanol

Vorschrift

To a solution of tert-butyl[(1S)-1-benzyl-2-oxo-2-{[4-(4-pyridinyl)phenyl]amino}ethyl]carbamate (800 mg) in ethanol (30 mL) was added 4N hydrogen chloride in ethyl acetate (5 mL) and the mixture was stirred at 60° C. for 1 hour. The solvents were removed by evaporation in vacuo and the residue was recrystallized from 2-propanol to afford (2S)-2-amino-3-phenyl-N-[4-(4-pyridinyl)phenyl]propanamide dihydrochloride (625 mg) as a white powder.

Quelle