Reaktion #159724

ord-18cf7095cbb0425bb13a39424d2ad15f

Reaktionsgleichung

CC(C)(C)OC(=O)N1CC[C@H](Oc2cccc(F)c2)C1
(S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate
COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3Cl)CC2)cc1
methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate
→
COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC[C@H](Oc4cccc(F)c4)C3)CC2)cc1
title compound ( D204 )
Ausbeute 111.9%
COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3N3CC[C@H](Oc4cccc(F)c4)C3)CC2)cc1
(S)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate
Ausbeute 111.9%

Edukte

CC(C)(C)OC(=O)N1CC[C@H](Oc2cccc(F)c2)C1
(S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate
COC(=O)c1ccc(C2(NC(=O)c3cc(Cl)cnc3Cl)CC2)cc1
methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (D204) (101 mg) was prepared according to the experimental procedure described in Description 160 starting from (S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate (D46) (100 mg, 0.355 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D) (D021/056/3) (65 mg, 0.177 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08828987B2uspto-grants-2014_09