Reaktion #1596978

ord-2dfc2ce301f24088acdd8e062b4dee75

Reaktionsgleichung

CN1CCNCC1
N-methylpiperazine
O=[N+]([O-])c1ccc(F)cc1-c1nc2ccccc2s1
2-(2′-nitro-5′-fluorophenyl)benzothiazole
O=C([O-])[O-].[K+].[K+]
K2CO3
→
CN1CCNCC1c1ccc([N+](=O)[O-])c(-c2nc3ccccc3s2)c1
2-(2′-Nitro-5′-(N-methylpiperazinyl)phenyl)benzothiazole

Edukte

CN1CCNCC1
N-methylpiperazine
O=[N+]([O-])c1ccc(F)cc1-c1nc2ccccc2s1
2-(2′-nitro-5′-fluorophenyl)benzothiazole
O=C([O-])[O-].[K+].[K+]
K2CO3

Reagenzien

Keine

Lösungsmittel

CS(C)=O
dimethyl sulfoxide

Reaktionsbedingungen

Temperatur
90°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

0.31 g (0.0030 mol) of N-methylpiperazine was added to the mixture of 0.41 g (0.015 mol) of 2-(2′-nitro-5′-fluorophenyl)benzothiazole and 0.32 g (0.0023 mol) of K2CO3 in 5 ml of dimethyl sulfoxide. The reaction was stirred magnetically and heated at 90° C., the progression thereof being verified by TLC.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08211662B2uspto-grants-2012_07