Reaktion #159655

ord-12374997667c4aee9c09d06757e67123

Reaktionsgleichung

COC(=O)c1cc(C(F)(F)F)cnc1N1CC(OS(C)(=O)=O)C1
methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate
Oc1cccc(Cl)c1
3-Chlorophenol
→
O=C(O)c1cc(C(F)(F)F)cnc1N1CC(Oc2cccc(Cl)c2)C1
title compound ( D124 )
Ausbeute 88.4%
O=C(O)c1cc(C(F)(F)F)cnc1N1CC(Oc2cccc(Cl)c2)C1
2-(3-(3-chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Ausbeute 88.4%

Edukte

—
103A
COC(=O)c1cc(C(F)(F)F)cnc1N1CC(OS(C)(=O)=O)C1
methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate
Oc1cccc(Cl)c1
3-Chlorophenol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (D124) (85 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 3-Chlorophenol (0.035 ml, 0.338 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08828987B2uspto-grants-2014_09