Reaktion #159640

Reaktionsgleichung

methyl 2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinate

lithium hydroxide monohydrate

→

title compound ( D100 )

Ausbeute 97.8%

2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinic acid

Ausbeute 97.8%

Lösungsmittel

1,4-dioxane water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSolvents were evaporated in vacuo
2. 2
   workup.ADDITIONThe obtained residue was diluted with water/1M HCl (5 ml/15 ml)
3. 3
   Extraktionextracted with ethyl acetate (3×30 ml)
4. 4
   SonstigeCollected fractions after solvent evaporation

Vorschrift

To methyl 2-(2-benzylpyrrolidin-1-yl)-5-chloronicotinate (D74) (75 mg, 0.226 mmol) in a mixture 1,4-dioxane/water (3 ml/1 ml), lithium hydroxide monohydrate (14.3 mg, 0.34 mmol) was added and the resulting mixture was stirred at 150° C. under microwave irradiation for 10 min (2 cycles of 5 min each). Solvents were evaporated in vacuo. The obtained residue was diluted with water/1M HCl (5 ml/15 ml) and extracted with ethyl acetate (3×30 ml). Collected fractions after solvent evaporation afforded the title compound (D100) (70 mg).

Quelle