Reaktion #159606

ord-4c56f6efe6d34c7cb22aed7d2cf12c39

Reaktionsgleichung

CC(C)(C)OC(=O)N1CC(O)C1
1-Boc-3-hydroxyazetidine
Oc1cccc(C(F)(F)F)c1
3-(Trifluoromethyl)phenol
→
FC(F)(F)c1cccc(OC2CNC2)c1
title compound
Ausbeute 8.0%
FC(F)(F)c1cccc(OC2CNC2)c1
3-(3-(trifluoromethyl)phenoxy)azetidine
Ausbeute 8.0%

Edukte

CC(C)(C)OC(=O)N1CC(O)C1
1-Boc-3-hydroxyazetidine
Oc1cccc(C(F)(F)F)c1
3-(Trifluoromethyl)phenol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (D53) (100 mg) was prepared according to the experimental procedure described in Description 52 starting from 1-Boc-3-hydroxyazetidine (1 g, 5.77 mmol) and 3-(Trifluoromethyl)phenol (0.69 ml, 5.77 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08828987B2uspto-grants-2014_09