Reaktion #1594973

Reaktionsgleichung

water

2-(4-fluorobenzyl)-7-(methylthio)thiazolo[5,4-d]pyrimidin-5-amine

NaOH

iodomethane

→

title compound

Ausbeute 69.1%

2-(1-(4-fluorophenyl)ethyl)-7-methylthio-thiazolo[5,4-d]pyrimidin-5-amine

Ausbeute 69.1%

Lösungsmittel

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate, brine
2. 2
   Trocknendried over Na2SO4
3. 3
   SonstigeAfter removing the solvents under reduced pressure
4. 4
   Sonstigethe residue was purified by chromatography on silica gel (hexane/EtOAc 5:1)

Vorschrift

To a solution of 2-(4-fluorobenzyl)-7-(methylthio)thiazolo[5,4-d]pyrimidin-5-amine (0.4 g, 1.31 mmol) and 2N NaOH (0.65 ml, 1.31 mmol) in DMSO (7 ml) was added iodomethane (81 μl, 1.31 mmol). The reaction mixture was stirred at room temperature for 2 hours. The mixture was poured into water and extracted with ethyl acetate, brine and dried over Na2SO4. After removing the solvents under reduced pressure, the residue was purified by chromatography on silica gel (hexane/EtOAc 5:1) yielding the title compound as a white solid (0.29 g, 69%).

Quelle