Reaktion #159410

ord-83190fffe4fd420d93480431c79ae603

Reaktionsgleichung

COC(=O)c1sc(C(=O)C(C)C)cc1N=CN(C)C
3-(Dimethylaminomethyleneamino)-5-isobutyrylthiophene-2-carboxylic acid methyl ester
CN1CCCN(c2ccc(N)cc2)CC1
4-(4-methyl[1,4]diazepan-1-yl)phenylamine
→
CC(C)C(=O)c1cc2ncn(-c3ccc(N4CCCN(C)CC4)cc3)c(=O)c2s1
6-Isobutyryl-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Edukte

COC(=O)c1sc(C(=O)C(C)C)cc1N=CN(C)C
3-(Dimethylaminomethyleneamino)-5-isobutyrylthiophene-2-carboxylic acid methyl ester
CN1CCCN(c2ccc(N)cc2)CC1
4-(4-methyl[1,4]diazepan-1-yl)phenylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product with the molecular weight of 410.54 (C22H26N4O2S) was obtained in this way

Vorschrift

3-(Dimethylaminomethyleneamino)-5-isobutyrylthiophene-2-carboxylic acid methyl ester and 4-(4-methyl[1,4]diazepan-1-yl)phenylamine were reacted by method A1. The product with the molecular weight of 410.54 (C22H26N4O2S) was obtained in this way; MS (ESI): 411 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08828991B2uspto-grants-2014_09