Reaktion #159402

ord-c891f24b1c6241f69c6e1550d7ac7083

Reaktionsgleichung

COC(=O)c1sc(C(=O)C2CCOCC2)cc1NC(=O)C(F)(F)F
5-(Tetrahydropyran-4-carbonyl)-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
COC(=O)c1sc(C(=O)C2CCOCC2)cc1N
3-Amino-5-(tetrahydropyran-4-carbonyl)thiophene-2-carboxylic acid methyl ester

Edukte

COC(=O)c1sc(C(=O)C2CCOCC2)cc1NC(=O)C(F)(F)F
5-(Tetrahydropyran-4-carbonyl)-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product with the molecular weight of 269.32 (C12H15NO4S) was obtained in this way

Vorschrift

5-(Tetrahydropyran-4-carbonyl)-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester and potassium carbonate were reacted by method X. The product with the molecular weight of 269.32 (C12H15NO4S) was obtained in this way; MS (ESI): 270 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08828991B2uspto-grants-2014_09