Reaktion #159376

Reaktionsgleichung

4-fluoro-2-methyl-1-nitrobenzene

dimethylpyrrolidin-3-ylamine

potassium carbonate

→

Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was partitioned between water and ethyl acetate
2. 2
   SonstigeThe organic phase was dried
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

Vorschrift

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

Quelle