Reaktion #159374

Reaktionsgleichung

3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester

dimethoxymethyldimethylamine

→

5-(4-Chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction solution was partitioned between water and ethyl acetate
2. 2
   TrocknenThe organic phase was dried over magnesium sulfate
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way

Vorschrift

A solution of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester (5.0 g) in DMF (30 μL) was mixed with dimethoxymethyldimethylamine (5 mL) and stirred for 36 hours. The reaction solution was partitioned between water and ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way; MS (ESI): 323 (M+H+).

Quelle