Reaktion #159373

Reaktionsgleichung

(S)-1-(4-(1-methyl-7-(3-methylmorpholino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)-3-(oxetan-3-yl)urea

2-(methylsulfonyl)ethanamine hydrochloride

→

(5)-1-(4-(1-methyl-7-(3-methylmorpholino)-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)phenyl)-3-(2-(methylsulfonyl)ethyl)urea

Reaktionsbedingungen

Vorschrift

This compound was prepared in an analogous fashion to (S)-1-(4-(1-methyl-7-(3-methylmorpholino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)-3-(oxetan-3-yl)urea, using 2-(methylsulfonyl)ethanamine hydrochloride as the starting material. 1H NMR (DMSO-d6, 400 MHz) δ ppm 8.96 (s, 1H), 8.25 (d, J=8.8 Hz, 2H), 8.21 (s, 1H), 7.51 (d, J=8.8 Hz, 2H), 6.42 (t, J=5.9 Hz, 1H), 4.25 to 4.13 (m, 4H), 3.96 to 3.83 (m, 2H), 3.78 to 3.79 (m, 1H), 3.79 to 3.60 (m, 2H), 3.60 to 3.47 (m, 3H), 3.37 to 3.30 (m, 5H), 1.27 (d, J=6.5 Hz, 3H); LC-MS m/z (method C1)=474.2 [M+H]+, RT=3.13 min

Quelle