Reaktion #159144

Reaktionsgleichung

(S)-2-benzyl 1-tert-butyl 4-oxopyrrolidine-1,2-dicarboxylate

HCl

→

(S)-benzyl 4-oxopyrrolidine-2-carboxylate hydrochloride

Lösungsmittel

tetrahydrofuran

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethree times with toluene on rotovap to dryness to remove all the excess acid
2. 2
   Sonstigefurther dried on a high vacuum overnight

Vorschrift

To a stirring solution of (S)-2-benzyl 1-tert-butyl 4-oxopyrrolidine-1,2-dicarboxylate (2.82 g, 8.8 mmol) in anhydrous tetrahydrofuran (44 mL) was added 4N HCl in 1,4-dioxane (9.3 mL) at room temperature. The mixture was stirred for 18 hours at room temperature. The product was then three times with toluene on rotovap to dryness to remove all the excess acid and further dried on a high vacuum overnight and used as is in the next step. Quantitative yield.

Quelle