Reaktion #159072

Reaktionsgleichung

5-Aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-methyl ester

LiOH

HCl

→

5-Aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester

Lösungsmittel

THF

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic solvents were removed in vacuo
2. 2
   workup.ADDITIONThe crude mixture was diluted with water and EtOAc
3. 3
   Sonstigethe organic layer was collected
4. 4
   SonstigeAll volatiles were removed in vacuo
5. 5
   Sonstigethe crude acid was used without further purification

Vorschrift

5-Aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-methyl ester (244 mg, 0.840 mmol) was dissolved in THF (2.0 mL)/MeOH (1.5 mL). An aqueous solution of LiOH (35.5 mg, 0.84 mmol) was added and stirring at room temperature was continued. After 3 hours, the reaction was neutralized with aqueous HCl (1M) and the organic solvents were removed in vacuo. The crude mixture was diluted with water and EtOAc and the organic layer was collected. All volatiles were removed in vacuo and the crude acid was used without further purification. LCMS-ESI+: calc'd for C15H17NO4: 275.3 (M+). Found: 276.3 (M+H+).

Quelle