Reaktion #1590392

Reaktionsgleichung

3-chloro[1,4]benzodioxino[2,3-c]pyridazine

sodium iodide

hydrogen iodide

→

3-iodo[1,4]benzodioxino[2,3-c]pyridazine

Ausbeute 27.6%

Lösungsmittel

ethyl acetate

sodium hydrogen carbonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Extraktionthe mixture was extracted
3. 3
   TrocknenThe organic layer was dried over anhydrous sodium sulfate
4. 4
   Einengenthe solvent was concentrated under reduced pressure

Vorschrift

Under an argon atmosphere, 3-chloro[1,4]benzodioxino[2,3-c]pyridazine (5.0 g), sodium iodide (6.79 g) and hydrogen iodide (55%) (57.98 g) were added and the mixture was stirred at 140° C. for 1 hr. The reaction mixture was diluted with ethyl acetate and aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted. The organic layer was dried over anhydrous sodium sulfate, and the solvent was concentrated under reduced pressure to give 3-iodo[1,4]benzodioxino[2,3-c]pyridazine (1.95 g).

Quelle