Reaktion #158999

Reaktionsgleichung

4-Amino-N-(4-amino-phenyl)-benzamide

pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

1-ethoxycarbonyl-1,2-dihydroquinoline

→

pyrrolidine-1-carboxylic acid tert-butyl ester

Ausbeute 146.6%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated under vacuum
2. 2
   workup.DISSOLUTIONOil was dissolved in ethyl acetate
3. 3
   Sonstigeforming a precipitate, which
4. 4
   Filtrationwas collected by vacuum filtration
5. 5
   Sonstigedried under vacuum

Vorschrift

4-Amino-N-(4-amino-phenyl)-benzamide (3.00 g) and pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (6.55 g) were dissolved in DCM (90 mL), and 1-ethoxycarbonyl-1,2-dihydroquinoline (7.88 g) was added. The reaction mixture was stirred at ambient temperature for 17 hours and evaporated under vacuum. Oil was dissolved in ethyl acetate, forming a precipitate, which was collected by vacuum filtration and dried under vacuum, giving 2-(4-{-4-[(pyrrolidine-1′-carboxylic acid tert-butyl ester)-phenylcarbamoyl}-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (7.64 g, 93%) as a white solid.

Quelle