Reaktion #158723

ord-08efbd127163432e91321c6abd1742e6

Reaktionsgleichung

COC(=O)c1cc([N+](=O)[O-])ccc1O
methyl 2-hydroxy-5-nitrobenzoate
O=S(=O)([O-])[O-].[Na+].[Na+]
Na2SO4
CO
MeOH
→
COC(=O)c1cc(N)ccc1OC
methyl 5-amino-2-methoxybenzoate

Edukte

COC(=O)c1cc([N+](=O)[O-])ccc1O
methyl 2-hydroxy-5-nitrobenzoate
O=S(=O)([O-])[O-].[Na+].[Na+]
Na2SO4
CO
MeOH

Reagenzien

[Pd]
Pd—C

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The hydrogenation of methyl 2-hydroxy-5-nitrobenzoate (700 mg, 3.3 mmol) using 10% Pd—C (100 mg) and Na2SO4 (100 mg) in MeOH at 50 psi gave methyl 5-amino-2-methoxybenzoate (600 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822685B2uspto-grants-2014_09