Reaktion #158697

ord-c6e3beb385354e8c9c7fdd0fec56f57d

Reaktionsgleichung

Oc1cccc(Nc2nc(Cl)ncc2F)c1
2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine
CC(C)c1ccc(N)cc1
4-isopropylaniline
→
CC(C)c1ccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)cc1
5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine

Edukte

Oc1cccc(Nc2nc(Cl)ncc2F)c1
2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine
CC(C)c1ccc(N)cc1
4-isopropylaniline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeIn like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine

Vorschrift

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 4-isopropylaniline gave 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 23.08 min.; purity: 99%; MS (m/e): 439 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822685B2uspto-grants-2014_09