Reaktion #158540

ord-5f1b985421824d27b6a6179a5339cc9c

Reaktionsgleichung

Fc1cnc(Cl)nc1Cl
2,4-dichloro-5-fluoropyrimidine
COc1ccc(N)cc1O
3-hydroxy-4-methoxylaniline
COc1ccc(Nc2ncc(F)c(Nc3ccc(OC)c(O)c3)n2)cc1O
N2,N4-bis(3-hydroxy-4-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In like manner to N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 3-hydroxy-4-methoxylaniline were reacted to yield N2,N4-bis(3-hydroxy-4-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 7.82 (d, 1H J=4 Hz), 7.18 (m, 2H), 6.95 (m, 2H), 6.83 (m, 2H) 3.93 (s, 6H); LCMS: ret. time: 16.63 min.; purity: 97%; MS (m/e): 373 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08822685B2uspto-grants-2014_09