Reaktion #158476

Reaktionsgleichung

2,4-dichloro-5-fluoropyrimidine

3-methoxycarbonyl-5-trifluoromethylaniline

→

2-chloro-5-fluoro-N4-(3-methoxycarbonyl-5-trifluoromethylphenyl)-4-pyrimidineamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine

Vorschrift

In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 3-methoxycarbonyl-5-trifluoromethylaniline gave 2-chloro-5-fluoro-N4-(3-methoxycarbonyl-5-trifluoromethylphenyl)-4-pyrimidineamine. 1H NMR (CD3OD): δ 8.60 (s, 1H), 8.43 (s, 1H), 8.20 (d, 1H, J=3 Hz), 7.99 (s, 1H), 3.96 (s, 3H); 19F NMR (CD3OD): −18332, −18374; and −44259; LCMS: purity: 91%; MS (m/e): 350 (MH+).

Quelle