Reaktion #1584567

Reaktionsgleichung

bis(2-methoxyethyl) azodicarboxylate

1-(2,3-dimethyl-2H-indazol-5-yl)-4-hydroxypyridin-2(1H)-one

(5-bromothiophen-2-yl)methanol

triphenylphosphine

→

title compound

Ausbeute 15.4%

4-[(5-bromothiophen-2-yl)methoxy]-1-(2,3-dimethyl-2H-indazol-5-yl)pyridin-2(1H)-one

Ausbeute 15.4%

Lösungsmittel

ethyl acetate

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water and saturated brine
2. 2
   Trocknendried over anhydrous magnesium sulfate
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   SonstigeThe obtained residue was purified by silica gel column chromatography (ethyl acetate/methanol)

Vorschrift

To a suspension of 1-(2,3-dimethyl-2H-indazol-5-yl)-4-hydroxypyridin-2(1H)-one (50 mg), (5-bromothiophen-2-yl)methanol (76 mg) and triphenylphosphine (154 mg) in tetrahydrofuran (5 ml) was added bis(2-methoxyethyl) azodicarboxylate (138 mg) at room temperature, and the mixture was stirred at the same temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (13 mg).

Quelle