Reaktion #158446

Reaktionsgleichung

2-(2-phenyltetrahydro-2H-pyran-2-yl)acetaldehyde

sulfamic acid

sodium chlorite

→

2-(2-phenyltetrahydro-2H-pyran-2-yl)acetic acid

Lösungsmittel

THF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThen the product was extracted with EtOAc (3×)
2. 2
   Waschenthe combined extracts were washed with brine
3. 3
   Trocknendried over Na2SO4
4. 4
   Sonstigeevaporated

Vorschrift

To a solution of 2-(2-phenyltetrahydro-2H-pyran-2-yl)acetaldehyde (100 mg, 0.490 mmol) and sulfamic acid (57.0 mg, 0.587 mmol) in THF (1.5 mL) was added a solution of sodium chlorite (53.1 mg, 0.587 mmol) in water (1.5 mL) dropwise, and the mixture was stirred at room temperature for 3 hrs. Then the product was extracted with EtOAc (3×) and the combined extracts were washed with brine, dried over Na2SO4, and evaporated to give 2-(2-phenyltetrahydro-2H-pyran-2-yl)acetic acid as oil. LC/MS: m/e 221.14 (M+H)+.

Quelle