Reaktion #1584438

ord-c67a36ea46704f6d92d9896283bef620

Reaktionsgleichung

Nc1ccc(C(F)(F)F)cc1C(=O)c1ccccc1
(2-amino-5-trifluoromethyl-phenyl)-phenyl-methanone
N#CCC(=O)C1CCCCC1
3-cyclohexyl-3-oxo-propionitrile
N#CCC(=O)C1CCCCC1
3-Cyclohexyl-3-oxo-propionitrile
→
N#Cc1c(C2CCCCC2)nc2ccc(C(F)(F)F)cc2c1-c1ccccc1
title compound
N#Cc1c(C2CCCCC2)nc2ccc(C(F)(F)F)cc2c1-c1ccccc1
2-Cyclohexyl-4-phenyl-6-trifluoromethyl-quinoline-3-carbonitrile

Edukte

Nc1ccc(C(F)(F)F)cc1C(=O)c1ccccc1
(2-amino-5-trifluoromethyl-phenyl)-phenyl-methanone
N#CCC(=O)C1CCCCC1
3-cyclohexyl-3-oxo-propionitrile
N#CCC(=O)C1CCCCC1
3-Cyclohexyl-3-oxo-propionitrile

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared in analogy to example 101 step B from (2-amino-5-trifluoromethyl-phenyl)-phenyl-methanone and 3-cyclohexyl-3-oxo-propionitrile (prepared as described in example 110 step A). Off-white solid. MS (ESI): 381.4 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09199938B2uspto-grants-2015_12