Reaktion #1584437

ord-90f8e2460f7348ae9735ffc647bb787b

Reaktionsgleichung

Nc1cc(F)c(Cl)cc1C(=O)c1ccccc1
(2-amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone
Nc1cc(F)c(Cl)cc1C(=O)c1ccccc1
(2-Amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone
N#CCC(=O)C1CCCCC1
3-cyclohexyl-3-oxo-propionitrile
N#CCC(=O)C1CCCCC1
3-Cyclohexyl-3-oxo-propionitrile
N#Cc1c(C2CCCCC2)nc2cc(F)c(Cl)cc2c1-c1ccccc1
title compound
N#Cc1c(C2CCCCC2)nc2cc(F)c(Cl)cc2c1-c1ccccc1
6-Chloro-2-cyclohexyl-7-fluoro-4-phenyl-quinoline-3-carbonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared in analogy to example 101 step B from (2-amino-5-chloro-4-fluoro-phenyl)-phenyl-methanone (prepared as described in example 105 step D) and 3-cyclohexyl-3-oxo-propionitrile (prepared as described in example 110 step A). Off-white solid. MS (ESI): 365.4 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09199938B2uspto-grants-2015_12