Reaktion #158418

Reaktionsgleichung

HCl

NaOH

ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate

NaOH

→

3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid

Ausbeute 100.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGto stir for 3 hrs
2. 2
   Extraktionthe product was extracted with EtOAc
3. 3
   WaschenThe extract was washed with water and brine
4. 4
   Trocknendried over Na2SO4
5. 5
   Sonstigeevaporated

Vorschrift

To a solution of ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate (540 mg, 1.822 mmol) in MeOH (15 mL) was added 1N NaOH (3.64 mL, 3.64 mmol), and the mixture was stirred at room temperature for 20 hrs. Since the reaction was not complete on TLC, an additional 1.82 mL of 1N NaOH was added, and it was continued to stir for 3 hrs. TLC showed that the reaction was complete. Next, the reaction mixture was acidified with the addition of 6 mL of 1N HCl, and the product was extracted with EtOAc. The extract was washed with water and brine, dried over Na2SO4, and evaporated to give 3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid (489 mg, 1.822 mmol, 100% yield) as a white solid.

Quelle