Reaktion #158392

Reaktionsgleichung

5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole

5-chloropent-1-yne

triethylamine

→

title compound

5-[4-(5-chloropent-1-yn-1-yl)-2-methoxyphenyl]-2-methyl-1,3-oxazole

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe mixture was filtered through celite
2. 2
   SonstigeThe solvent was evaporated under reduced pressure
3. 3
   Sonstigethe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Vorschrift

A mixture of 5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole (6.00 g), 5-chloropent-1-yne (4.74 mL), dichlorobis(triphenylphosphine)palladium(II) (1.57 g), copper(I) iodide (426 mg) and triethylamine (60 mL) was stirred at 70° C. for 3 hr, and diluted with ethyl acetate, and the mixture was filtered through celite. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (4.85 g).

Quelle