Reaktion #1583879

Reaktionsgleichung

2,2-diphenyl ethanol

triethylamine

MsCl

→

2,2-diphenylethyl methanesulfonate

Ausbeute 96.8%

Lösungsmittel

dichloromethane

—

three-opening

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas conducted at 25° C
2. 2
   SonstigeAfter the completion of reaction
3. 3
   Waschenthe reaction solution was washed with water thrice
4. 4
   TrocknenThe organic phase was dried over anhydrous sodium sulfate
5. 5
   Sonstigeevaporated
6. 6
   Sonstigeto remove the solvent

Vorschrift

In a 500 mL three-opening flask, 2,2-diphenyl ethanol (17 g, 86 mmol) was dissolved in 170 mL dichloromethane. To the flask was added triethylamine (13.03 g, 129 mmol). The resulting mixture was stirred at 0° C. for half an hour. To the resulting mixture was slowly added MsCl (11.92 g, 104 mmol) dropwisely. The reaction was conducted at 25° C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23 g) in a yield of 96.78%.

Quelle