Reaktion #1583862

ord-7e3c225e53e842df8aa1cb96825465d1

Reaktionsgleichung

Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
dextromethorphan HBr
→
COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
Dextromethorphan

Edukte

Br.COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
dextromethorphan HBr

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Temperatur
77.5°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONfollowed by the addition of 175.82 g AMBERLITE IRP-69 resin (anhydrous)
  2. 2
    workup.ADDITIONunder gentle mixing for 4 hours
  3. 3
    Sonstigedecanted
  4. 4
    Waschenrinsed with purified water twice
  5. 5
    Sonstigedried in an oven
  6. 6
    Temperaturmaintained at 50° C. until moisture
  7. 7
    Filtrationsieved through a 40 mesh screen

Vorschrift

The Uncoated Dextromethorphan Resin Complex was prepared by first dissolving 95.42 g of dextromethorphan HBr in 0.8 L of purified water heated to 75-80° C., followed by the addition of 175.82 g AMBERLITE IRP-69 resin (anhydrous) under gentle mixing for 4 hours. At the completion, the suspension was allowed to settle, decanted and rinsed with purified water twice and dried in an oven maintained at 50° C. until moisture is around 5%. The dried resin complex was hand sieved through a 40 mesh screen.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09198864B2uspto-grants-2015_12