Reaktion #158323

Reaktionsgleichung

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid

hydrazine monohydrate

→

title compound

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled to −10° C.
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 2 hr
3. 3
   SonstigeThe solvent was evaporated under reduced pressure, and water
4. 4
   workup.ADDITIONwas added
5. 5
   FiltrationThe precipitated solid was collected by filtration

Vorschrift

To a suspension of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid (5 g) in THF (60 mL) was added N,N′-carbonyldiimidazole (6.98 g) at room temperature, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was cooled to −10° C., hydrazine monohydrate (10.44 mL) was added, and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure, and water was added. The precipitated solid was collected by filtration to give the title compound (0.70 g).

Quelle