Reaktion #158147

Reaktionsgleichung

N-[2-(6-Chloro-4-formyl-2H-benzotriazol-2-yl)-1-cyano-1-methylethyl]-4-trifluoromethoxybenzamide

2-methyl-2-butene

sodium hypochlorite

sodium dihydrogen phosphate

→

title compound

Ausbeute 87.0%

6-Chloro-2-[2-cyano-2-({[4-(trifluoromethoxy)phenyl]carbonyl}amino)-propyl]-2H-benzotriazole-4-carboxylic acid

Ausbeute 87.0%

Lösungsmittel

THF

t-butanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with water (50 mL)
3. 3
   FiltrationThe white solid was filtered
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried under vacuum

Vorschrift

To a solution of N-[2-(6-Chloro-4-formyl-2H-benzotriazol-2-yl)-1-cyano-1-methylethyl]-4-trifluoromethoxybenzamide (1.5 g) in a mixture of THF (25 mL), t-butanol (10 mL) and 2-methyl-2-butene was added dropwise the solution of sodium hypochlorite (0.9 g) and sodium dihydrogen phosphate (1.15 g) in water (20 mL). After 4 hour at room temperature, the mixture was concentrated under reduced pressure, diluted with water (50 mL) and acidified to pH 2 with normal HCl. The white solid was filtered and washed with water and dried under vacuum to give the title compound (1.35 g, 87%). MS (ES): M/Z [M+H]=468. 1H NMR: (400 MHz, DMSO-d6): 1.72 (s, 3H), 5.48-5.64 (m, 2H), 7.43 (d, J=8.2 Hz, 2H), 7.83 (d, J=2.0 Hz, 1H), 7.99 (d, J=8.8 Hz, 2H), 8.23 (d, J=1.8 Hz, 0H) and 9.41 (br. s., 1H). 19F NMR (376 MHz, DMSO-d6): −57.1 (s, 3F).

Quelle