Reaktion #1579022

Reaktionsgleichung

2-(acetylaminomethyl)-6-bromoacetyl-pyridine hydrobromide

diaminomethylenethiourea

→

4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

Ausbeute 42.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 10 hours
2. 2
   SonstigeThe resulting precipitate was collected
3. 3
   workup.DISSOLUTIONdissolved in water (50 ml)
4. 4
   SonstigeThe separated product was collected
5. 5
   Waschenwashed with water

Vorschrift

A mixture of 2-(acetylaminomethyl)-6-bromoacetyl-pyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

Quelle