Reaktion #157687

Reaktionsgleichung

methyl iodide

ethyl 5-cyclopropyl-6-hydroxypyridine-2-carboxylate

→

ethyl 5-cyclopropyl-6-methoxypyridine-2-carboxylate

Ausbeute 99.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction solution was filtered through celite
2. 2
   Sonstigethe solvent was evaporated under reduced pressure
3. 3
   SonstigeThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1→4:1)

Vorschrift

Silver carbonate (70 g) and methyl iodide (11.2 mL) were added to a solution of ethyl 5-cyclopropyl-6-hydroxypyridine-2-carboxylate (12.4 g) in chloroform (250 mL), and the mixture was stirred at 60° C. for eight hours. The reaction solution was filtered through celite, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1→4:1) to give ethyl 5-cyclopropyl-6-methoxypyridine-2-carboxylate (13.05 g, 99%) as a colorless oil.

Quelle