Reaktion #157439

Reaktionsgleichung

trimethylaluminum

2-chloroethyl p-toluenesulfonate

potassium carbonate

ammonium chloride

ethyl 5-(4-hydroxyphenyl)-2-thiophene carboxylate

→

title compound

5-{4-[(2-chloroethyl)oxy]phenyl}-2-thiophenecarboxamide

Lösungsmittel

toluene

acetonitrile

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturcooled to 5° C.
3. 3
   Sonstigequenched with ethanol (10 ml)
4. 4
   SonstigeAll solvents were removed in vacuo
5. 5
   workup.ADDITIONthe residue was treated with 80 ml of 0.5M HCl solution
6. 6
   FiltrationA yellow solid was collected by filtration
7. 7
   Waschenwashed with water
8. 8
   Sonstigeair-dried (1.64 g)
9. 9
   TemperaturAfter heating
10. 10
    Temperaturat reflux for 40 h
11. 11
    Filtrationthe reaction mixture was filtered
12. 12
    Sonstigeto remove the solids
13. 13
    Einengenconcentrated to dryness in vacuo
14. 14
    Sonstigepurified by silica gel column chromatography

Vorschrift

To a suspension of ammonium chloride (2.12 g, 39.6 mmol) in 10 ml of toluene at 5° C. was added dropwise 19.8 ml of 2M trimethylaluminum in toluene solution. The mixture was stirred for 2 h at the room temperature and ethyl 5-(4-hydroxyphenyl)-2-thiophene carboxylate (Intermediate KK-1-1) (1.98 g, 7.03 mmol) was added. The resulting mixture was heated at 55-60° C. for 15 h, cooled to 5° C. and quenched with ethanol (10 ml). All solvents were removed in vacuo and the residue was treated with 80 ml of 0.5M HCl solution. A yellow solid was collected by filtration, washed with water and air-dried (1.64 g). The product was added to a mixture of 2-chloroethyl p-toluenesulfonate (4.07 ml, 22.5 mmol) and potassium carbonate (3.11 g, 22.5 mmol) in 100 ml of acetonitrile. After heating at reflux for 40 h, the reaction mixture was filtered to remove the solids, concentrated to dryness in vacuo and purified by silica gel column chromatography using Hexanes and EtOAc to give the title compound as a light yellow solid.

Quelle